李先伟
发布时间:2023-10-09 点击次数:31 发布部门:澳门人威尼斯4399李先伟,男,44岁,博士,教授,硕士生导师(药理学)。美国University of Maryland访问学者。现为安徽省药理学会理事,中国医药教育协会委员,芜湖市生物学会理事,《医药导报》杂志青年编委,已发表论文60余篇,其中SCI论文10余篇,参编著作6部。先后主持安徽省自然科学基金等项目5项,横向课题6项。承担研究生与本科生的《高级药理学》、《高级药学应用及实践技术》、《药理学》、《麻醉药理学》等课程教学工作。
【主要研究方向】肺纤维化和肺动脉高压的发病机制和药物防治。
【联系方式】20060075@wnmc.edu.cn
【教育学习经历】
1.2009/9–2012/6,中南大学,药理学,博士
2.2003/9–2006/6,皖南医学院,药理学,硕士
3.1998/9–2003/6,皖南医学院,临床医学,学士
【主要科研项目】
1. 2021年安徽省高校自然科学研究重大项目,醛糖还原酶介导的II型肺泡上皮细胞线粒体质量控制失调在上皮-间质转分化(EMT)中的作用机制研究,KJ2021ZD0106,2021.11-2024.11,20万,在研,主持
2.安徽省卫生健康委科研重点项目,基于上皮间质转分化(EMT)探讨依帕司他防治放射性肺损伤的机制,AHWJ2021a033,2021.6-2023.6,10万,在研,主持
3. 2018年安徽省高校自然科学研究重点项目,TGF-β1/MAPK/eIF
4. 安徽省自然科学基金青年基金项目,1408085QH168,降钙素基因相关肽对肺纤维化大鼠肺组织p27蛋白表达的影响,2014.06~2016.06,10万,结题,主持。
5. 高校优秀青年人才支持计划重点项目,降钙素基因相关肽对肺纤维化大鼠肺组织真核翻译起始因子
【近五年代表性论文】
1) Zhang Z, Li Z, Chen X, Wang Y, Li X. Effect of AR gene-specific knockout on the process of radiation-induced pulmonary fibrosis and its mechanism. Cell Mol Biol (Noisy-le-grand). 2023 May 31;69(5):156-162.
2) Ziyu Zhang, Wenqiang Gu, Zepeng Li, Xiao Chen, Wei Xu, Xianwei Li. Interleukin-33 promotes the epithelial-mesenchymal transition of renal tubular epithelial cells via the NF-κB/Twist1 signalling pathway. European Journal of Inflammation. 2023; 21:1-11
3) Gao Y, Fu Y, Chen X, Li Z, He X, Li X. IL-33 up-regulates eIF3a expression by activating NF-κB signaling pathway to mediate the proliferation and differentiation of mouse pulmonary myofibroblasts and aggravate pulmonary fibrosis. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2023 Aug;39(8):693-700.
4) Tang J, Ke J, Fu Y, He XW, Li XW. Effects of Notch-1/Twist-1 axis in the process of epithelial-mesenchymal transition of type II alveolar epithelial cell and its mechanism. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2021;37(6):577-583.
5) Lu LM, Fu Y, Li QY, He XW, Tang J, Li XW. Chrysin inhibited epithelial-mesenchymal transition of type Ⅱ alveolar epithelial cell by regulating NF-κB/Twist 1 signaling pathway. Zhongguo Zhong Yao Za Zhi. 2021 Jan;46(1):146-154.
6) Li XW#, Li XH, Du J, Li D, Li YJ, Hu CP. Calcitonin gene-related peptide down-regulates bleomycin-induced pulmonary fibrosis. Can J Physiol Pharmacol. 2018; 94:1315-1324.
7) Li XW, Wu YH, Li XH, Li D, Du J, Hu CP, Li YJ. Role of eukaryotic translation initiation factor
8) Li XW, Hu CP, Li YJ, Gao YX, Wang XM, Yang JR. Inhibitory effect of l-mimosine on bleomycin-induced pulmonary fibrosis in rats: Role of eIF
9) Xian-Wei Li, Yan Liu Wei Hao, and Jie-Ren Yang. Sequoyitol ameliorates diabetic nephropathy in diabetic rats induced by high-fat diet and low dose streptozotocin. Can J Physiol Pharmacol, 2014;92(5):405-417.
10) Xian-Wei Li, Xiang-Ming Wang, Shu Li, Jie-Ren Yang. Effects of chrysin (5, 7-dihydroxyflavone) on vascular remodeling in hypoxia-induced pulmonary hypertension in rats. Chinese Medicine, 2015;10:4.
11) Xian-Wei Li, Xiao-Hui Li, Gao-Yun Hu, Jie Du, Chang-Ping Hu, Yuan-Jian Li. Fluorofenidone attenuated vascular remodeling of hypoxia-induced pulmonary hypertension in rats via inhibiting TGF-β1 Expression. Can J Physiol Pharmacol, 2014;92(1):58-69.
12) Xianwei Li, Yuanyuan Shen, Yining Lu, and Jieren Yang.Amelioration of Bleomycin-induced Pulmonary Fibrosis of Rats by an Aldose Reductase Inhibitor, Epalrestat. Korean J Physiol Pharmacol. 2015,19(5):1-10.